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Anti-BSG Antibody EPR4053

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SKU Description Amount Price Availability*  
TA306979
  • Rabbit monoclonal antibody against CD147(clone EPR4053)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403688) , 20ug Explanation
100ul $325 3 Weeks
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WB(2)
IHC(2)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human CD147 was used as an immunogen.
Clone NameEPR4053 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens basigin (Ok blood group) (BSG), transcript variant 4
Alternative Name5F7; CD147; EMMPRIN; M6; OK; TCSF
Database LinkNP_940993
Entrez Gene 682 Human
FunctionCD147 is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It is also a member of the immunoglobulin superfamily (1). CD147 stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). It may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 is present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas (2).
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - CD147 antibody [EPR4053]; All lanes : Anti-CD147 antibody [EPR4053] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HuT-78 cell lysate.Lane 3 : A431 cell lysate.Lysates/proteins at 10 ug per lane.Performed under reducing conditions.Predicted band size : 42 kDa.
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Western blot - CD147 antibody [EPR4053]; Anti-CD147 antibody [EPR4053] at 1/1000 dilution + HeLa cell lysate at 10 ug.Performed under reducing conditions.Predicted band size : 42 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD147 antibody [EPR4053]; TA306979, at 1/250, staining CD147 in human glioma tissue by immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD147 antibody [EPR4053]; TA306979, at 1/250, staining human brain tissue by immunohistochemistry.
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