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Home Antibody All anti-BRSK2 antibodies

Anti-BRSK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306412
  • Rabbit Polyclonal BRSK2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401301) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for BRSK2 (NM_003957)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBRSK2 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human BRSK2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BR serine/threonine kinase 2 (BRSK2), transcript variant 2
Alternative NameC11orf7; PEN11B; SAD1; SADA; STK29
Database LinkNP_003948
FunctionBRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.
Related Pathway

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WB Image
Western blot analysis of BRSK2 in human brain tissue lysate with BRSK2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of BRSK2 in human brain tissue with BRSK2 antibody at 5 ug/ml.

 

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