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Home Antibody All anti-C13orf34 antibodies

Anti-C13orf34 Antibody EPR4456

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307043
  • Rabbit monoclonal antibody against BORA(clone EPR4456)
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human BORA was used as an immunogen.
Clone NameEPR4456 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens bora, aurora kinase A activator (BORA), transcript variant 1
Alternative NameC13orf34
Database LinkNP_079084
FunctionBORA is an activator of protein kinase Aurora A, which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (1). It is also a Plk1-interacting protein, which controls multiple transitions in mitosis and cytokinesis. One of Plk1's key biochemical functions is to phosphorylate its substrates and to target them for degradation by the SCF-β-TrCP ubiquitin ligase in the cell cycle. Degradation of BORA after mitotic entry releases Plk1 free to associate with prime-phosphorylated substrates, which enhance its kinase activity and target Plk1 to kinetochores and centrosomes for its mitotic function (2).
Related Pathway

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WB Image
Western blot - Bora antibody [EPR4456]; All lanes : Anti-Bora antibody [EPR4456] at 1/1000 dilution.Lane 1 : fetal brain lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : Y79 lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 61 kDa.

 

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