Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3), nuclear gene encoding mitochondrial protein
Synonyms:
NIP3
Immunogen
A synthetic peptide corresponding to residues in human NIP3 / BNIP3 was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
NIP3 / BNIP3 is a member of the BCL2/adenovirus E1B 19 kDa-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 / BNIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.
Related Pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis on (A) Jurkat treated with etoposide, (B) Jurkat, (C) SH-SY5Y treated with camptothecin, (D) SH-SY5Y, and (E) MCF-7 treated with Cocl2 cell lysates using anti-NIP3 / BNIP3 RabMAb .
