NIP3 / BNIP3 is a member of the BCL2/adenovirus E1B 19 kDa-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 / BNIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.
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Western blot analysis on (A) Jurkat treated with etoposide, (B) Jurkat, (C) SH-SY5Y treated with camptothecin, (D) SH-SY5Y, and (E) MCF-7 treated with Cocl2 cell lysates using anti-NIP3 / BNIP3 RabMAb .