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Home Antibody All anti-BMI1 antibodies

Anti-BMI1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301482
  • Rabbit Polyclonal Antibody against Bmi1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401584) , 20ug
100ul 325 In Stock
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WB(1)
IF(1)
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Also for BMI1 (NM_005180)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide made to an internal region (within residues 1-100) of the human Bmi1 protein. [Swiss-Prot# P35226]
Clone Name IsotypeIgG
Species Reactivityhuman, mouse Concentration1.09 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5-2 ug/ml
BufferTris-glycine, 150mM NaCl and 0.05% sodium azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens BMI1 proto-oncogene, polycomb ring finger (BMI1)
Alternative NameFLVI2/BMI1; PCGF4; RNF51
Database LinkNP_005171
FunctionThe Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.
Related Pathway
Senescence and Autophagy

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WB Image
Detection of Bmi1 protein in skeletal muscle
IF Image
Immunocytochemistry/Immunofluorescence: BMI1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

 

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