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Home Antibody All anti-BIRC6 antibodies

Anti-BIRC6 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319974
  • Rabbit Polyclonal BRUCE Antibody
100ug $325 3-7 Days
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IHC(1)

OriGene Data

ImmunogenBRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *IHC Suggested DilutionsELISA, IHC: 5 ug/ml
BufferBRUCE Antibody is supplied in PBS containing 0.02% sodium azide.
Purification BRUCE Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 6 (BIRC6)
Alternative NameAPOLLON; BRUCE
Database LinkNP_057336
FunctionBRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
Related Pathway

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IHC Image
Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 ug/mL.

 

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