Home Antibody All anti-BIRC6 antibodies
Anti-BIRC6 Antibody Polyclonal
Also for BIRC6 (NM_016252)
|BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE.|
||ELISA, IHC: 5 ug/ml
|BRUCE Antibody is supplied in PBS containing 0.02% sodium azide.|
|BRUCE Antibody is affinity chromatography purified via peptide column.
|Homo sapiens baculoviral IAP repeat containing 6 (BIRC6)|
Entrez Gene 57448 Human
|BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.|
|Druggable Genome Ubiquitin mediated proteolysis|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 ug/mL.