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Home Antibody All anti-BIRC5 antibodies

Anti-BIRC5 Antibody 32.1

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301427
  • Mouse Monoclonal Antibody against Survivin (32.1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400469) , 20ug Explanation
100ul 325 3-7 Days
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IHC(1)
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Also for BIRC5 (NM_001168)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant human survivin, full-length
Clone Name32.1 IsotypeIgG1 kappa
Species Reactivityhuman Concentration1.9 mg/ml
Guaranteed Application *IHC Suggested DilutionsWB: 1: 1000
Buffer0.1% sodium azide
Purification protein G purified

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 1
Alternative NameAPI4; EPR-1
Database LinkNP_001159
Entrez Gene 332 Human
FunctionRegulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a c-terminus RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.
Related PathwayStem cell - PluripotencyDruggable Genome Pathways in cancerColorectal cancer

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* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Staining of human lung, cancer

 

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