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Home Antibody All anti-BEST1 antibodies

Anti-BEST1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323888
  • Anti-BEST1 Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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IHC(1)
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Also for BEST1 (NM_004183)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 438-452 amino acids of human bestrophin 1
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:2000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens bestrophin 1 (BEST1), transcript variant 1
Alternative NameARB; BEST; BMD; RP50; TU15B; VMD2
Database LinkNP_004174
FunctionThis gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2); also known as Best macular dystrophy; in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using BEST1 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification: x200)

 

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