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Home Antibody All anti-BECN1 antibodies

Anti-BECN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301470
  • Rabbit Polyclonal Antibody against Beclin 1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401239) , 20ug
100ul 325 3-7 Days
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WB(2)
IHC(2)
IF(1)
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Also for BECN1 (NM_003766)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNB 500-249 was raised against an internal synthetic peptide to human Beclin 1, containing residues within 1-100. This sequence has 94% identity with the mouse sequence and 88% identity with the rat sequence.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:2000-1:5000
BufferTris-citrate/phosphate, pH 7-8 and 0.1% sodium azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens beclin 1, autophagy related (BECN1)
Alternative NameATG6; beclin1; VPS30
Database LinkNP_003757
FunctionBeclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses.
Related Pathway
Senescence and Autophagy

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WB Image
Detection of Beclin in mouse liver tissue lysate (50 ug). ECL detection at 1 minute
WB Image
Western Blot: Beclin 1 Antibody - WB analysis of Belclin1. Lane 1 human brain and Lane 2 mouse brain
IHC Image
Pheochromocytes of the Adrenal Medulla 40x
IHC Image
Immunohistochemistry-Paraffin: Beclin 1 Antibody - Analysis of Beclin1 in mouse kidney.
IF Image
Immunocytochemistry/Immunofluorescence: Beclin 1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

 

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