Home Antibody All anti-BCL2L11 antibodies
Also for BCL2L11 (NM_006538)
|Bim antibody was raised against a peptide corresponding to amino acids near the center of human Bim. The sequence is identical to that of mouse and differs from that of rat by one amino acid .|
|Human, Mouse, Rat
||WB: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6|
|BAM; BIM; BOD|
|Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1,2).|
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Western blot analysis of Bim in K562 (K) and A549 (A) whole cell lysates with Bim antibody at 1 ug/ml.
Immunohistochemistry of Bim in human skin cancer cells with Bim antibody at 20 ug/ml.