Home All anti-BCL2L1 antibodies
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Also for BCL2L1 (NM_001191)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 178 of BCL2L1|
|WB, IHC, IF
||WB:1:500-1:3000; IHC:1:500; IF:1:100-1:500;
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 2|
|Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52|
|The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq]|
Jak-STAT signaling pathway
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Sample (30 ug of whole cell lysate) A:NIH-3T3 ( anti-BCL2L1 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using BCL2L1(anti-BCL2L1 antibody) antibody at 1:500 dilution.
Immunofluorescence analysis of methanol-fixed A549, using BCL-x(anti-BCL2L1 antibody) antibody at 1:500 dilution.