Anti-BCL2L1 Antibody,

Also for BCL2L1 (NM_001191)

OriGene Data

Immunogen	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 178 of BCL2L1
Clone Name		Isotype
Species Reactivity	Human, Mouse	Concentration	0.95mg/ml
Guaranteed Application *	WB, IHC, IF	Suggested Dilutions	WB:1:500-1:3000; IHC:1:500; IF:1:100-1:500;
Buffer	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification	Purified by antigen-affinity chromatography. (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 2
Alternative Name	Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52
Database Link	NP_001182
Function	The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq]
Related Pathway	Apoptosis Jak-STAT signaling pathway

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WB Image

Sample (30 ug of whole cell lysate) A:NIH-3T3 ( anti-BCL2L1 antibody diluted at 1:1000)

IHC Image

Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using BCL2L1(anti-BCL2L1 antibody) antibody at 1:500 dilution.

IF Image

Immunofluorescence analysis of methanol-fixed A549, using BCL-x(anti-BCL2L1 antibody) antibody at 1:500 dilution.

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

HRP
Biotin
PE
FITC
DyLight® 488
DyLight® 550
DyLight® 594
DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-BCL2L1 Antibody

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data