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Home Antibody All anti-BCL2 antibodies

Anti-BCL2 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306171 Rabbit Polyclonal Bcl-2 Antibody 100ug $325 In Stock

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WB(1)
IHC(1)

OriGene Data

ImmunogenBcl-2 antibody was raised against a peptide corresponding to 15 amino acids near the N-terminus of human Bcl-2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant alpha
Alternative NameBcl-2; PPP1R50
Database LinkNP_000624
Entrez Gene 596 Human
Entrez Gene 12043 Mouse
FunctionApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis (reviewed in 2 and 3). These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis (4). It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad (5 for review). Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer (4,6).
Related PathwayES Cell Differentiation/IPSTransmembraneStem cell - PluripotencyDruggable Genome ApoptosisFocal adhesionNeurotrophin signaling pathwayAmyotrophic lateral sclerosis (ALS)Pathways in cancerColorectal cancerMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Bcl-2 in Daudi cell lysates with Bcl-2 antibody at (A) 1, (B) 2, and (C) 4 ug/ml.
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Immunohistochemical staining of human kidney using Bcl-2 antibody at 2 ug/ml.
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