Home Antibody All anti-BCCIP antibodies
Also for BCCIP (NM_016567)
|181 - 243 of Human BCCIP|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens BRCA2 and CDKN1A interacting protein (BCCIP), transcript variant A|
|This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]|
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A: A431 B: Hela (anti-BCCIP antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TOK-1 alpha (anti-BCCIP antibody) antibody at 1:200 dilution.