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Home Antibody All anti-BCCIP antibodies

Anti-BCCIP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308557
  • Rabbit polyclonal antibody to TOK-1 alpha (BRCA2 and CDKN1A interacting protein)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413842) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(2)
IF(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 181 and 273 of BCCIP (Uniprot ID#Q9P287)
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 36kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens BRCA2 and CDKN1A interacting protein (BCCIP), transcript variant A
Alternative NameTOK-1; TOK1
Database LinkNP_057651
Entrez Gene 56647 Human
FunctionThis gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Related PathwayStem cell - PluripotencyDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: A431 . B: Hela. 10% SDS PAGE. TA308557 diluted at 1:1000.
IHC Image
BCCIP antibody detects BCCIP protein at nucleus on BT483 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded BT483 xenograft. BCCIP antibody (TA308557) dilution: 1:500.
IHC Image
BCCIP antibody detects BCCIP protein at nucleus on U373 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U373 xenograft. BCCIP antibody (TA308557) dilution: 1:500.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using BCCIP (TA308557) antibody at 1:200 dilution.

 

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