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Anti-BCAR1 Antibody EPR1850(2)
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Also for BCAR1 (NM_014567)
|A synthetic peptide corresponding to residues in human p130Cas was used as an immunogen.|
|Human, Mouse, Rat
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6|
|CAS; CAS1; CASS1; CRKAS; P130Cas|
|Breast cancer anti-estrogen resistance protein 1 (p130Cas) is a docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (1). It has a defined function in cardiovascular development, actin filament assembly and Src-induced transformation (2). p130Cas is highly phosphorylated at tyrosines during transformation by v-Src, as well as by v-Crk, forming stable complexes with these oncoproteins. Cytoplasmic p130Cas has been shown to move to the membrane upon tyrosine phosphorylation. p130Cas is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins, and its unique structure indicates its possible role in assembling signals from multiple SH2-containing molecules (3). It is implicated in induction of cell migration, and over expression of p130Cas confers anti-estrogen resistance on breast cancer cells (1).|
EGFR1 Signaling Pathway
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Western blot analysis on (A) HeLa, (B) T47-D, (C) A431, (D) C6, (E) Raw264.7, (F) PC-12, and (G) NIH/3T3 cell lysates using anti-p130Cas RabMAb .