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Anti-BCAR1 Antibody EPR1850(2)
Also for BCAR1 (NM_014567)
|A synthetic peptide corresponding to residues in human p130Cas was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6|
|CAS; CAS1; CASS1; CRKAS; P130Cas|
Entrez Gene 9564 Human
Entrez Gene 12927 Mouse
Entrez Gene 25414 Rat
|Breast cancer anti-estrogen resistance protein 1 (p130Cas) is a docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (1). It has a defined function in cardiovascular development, actin filament assembly and Src-induced transformation (2). p130Cas is highly phosphorylated at tyrosines during transformation by v-Src, as well as by v-Crk, forming stable complexes with these oncoproteins. Cytoplasmic p130Cas has been shown to move to the membrane upon tyrosine phosphorylation. p130Cas is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins, and its unique structure indicates its possible role in assembling signals from multiple SH2-containing molecules (3). It is implicated in induction of cell migration, and over expression of p130Cas confers anti-estrogen resistance on breast cancer cells (1).|
|Druggable Genome Chemokine signaling pathwayFocal adhesionLeukocyte transendothelial migrationRegulation of actin cytoskeleton|
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Western blot - BCAR1 antibody [EPR1850(2)]; All lanes : Anti-BCAR1 antibody [EPR1850(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : T47-D cell lysate.Lane 3 : A431 cell lysate.Lane 4 : C6 cell lysate.Lane 5 : Raw264.7 cell lysate.Lane 6 : PC12 cell lysate.Lane 7 : NIH 3T3 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 93 kDa.