Home Antibody All anti-BBC3 antibodies
Anti-BBC3 Antibody N/A
Also for BBC3 (NM_001127240)
|C-terminal amino acids of human PUMA|
|Human, Mouse, Rat
||WB: 1:1000, ICC: 1:100
|PBS with 0.02% sodium azide|
|Detects a ~23kDa protein corresponding to the molecular mass of PUMA on SDS PAGE immunoblots. 16kDa bands may be seen in some instances, possibly corresponding to PUMAß.
|Homo sapiens BCL2 binding component 3 (BBC3), transcript variant 1|
|JFY-1; JFY1; PUMA|
|Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 up-regulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse . PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA- and PUMA- . PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.|
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Western blot analysis of PUMA in K562 human cell lysates (Left) and mouse 3T3 cell lysates (Right) using the antibody
ICC of PUMA in K562 cells using the antibody