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Home Antibody All anti-BBC3 antibodies

Anti-BBC3 Antibody N/A

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326343
  • Rabbit polyclonal PUMA/BBC3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426734) , 20ug Explanation
100µg 325 3-7 Days
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WB(1)
IF(1)
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Also for BBC3 (NM_001127240)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenC-terminal amino acids of human PUMA
Clone NameN/A IsotypeN/A
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000, ICC: 1:100
BufferPBS with 0.02% sodium azide
Purification Affinity Purified
Note Detects a ~23kDa protein corresponding to the molecular mass of PUMA on SDS PAGE immunoblots. 16kDa bands may be seen in some instances, possibly corresponding to PUMAß.

Reference Data

Target NameHomo sapiens BCL2 binding component 3 (BBC3), transcript variant 1
Alternative NameJFY-1; JFY1; PUMA
Database LinkNP_001120712
Entrez Gene 27113 Human
Entrez Gene 170770 Mouse
Entrez Gene 317673 Rat
FunctionApoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 up-regulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse . PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA- and PUMA- . PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Related PathwayDruggable Genome p53 signaling pathwayHuntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PUMA in K562 human cell lysates (Left) and mouse 3T3 cell lysates (Right) using the antibody
IF Image
ICC of PUMA in K562 cells using the antibody

 

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