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Anti-BBC3 Antibody 2A8F6
Also for BBC3 (NM_001127240)
|Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.|
||ELISA, WB: 2.5 - 5 ug/ml
|PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens BCL2 binding component 3 (BBC3), transcript variant 1|
|JFY-1; JFY1; PUMA|
|PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.|
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Western blot analysis of PUMA expression in K562 cell lysate with PUMA antibody at (A) 2.5 and (B) 5 ug/mL.