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Anti-BAP1 Antibody 1G8


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  • Mouse Monoclonal Antibody against BAP1 (1G8)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401476) , 20ug Explanation
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OriGene Data

ImmunogenFull-length human BAP1 protein expressed and purified from E.coli. [Uniprot# Q92560]
Clone Name1G8 IsotypeIgG1 kappa
Species Reactivityhuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 2 ug/ml
BufferTris-glycine, 150mM NaCl and 0.05% sodium azide
Purification protein G purified

Reference Data

Target NameHomo sapiens BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1)
Alternative NameHUCEP-13; hucep-6; UCHL2
Database LinkNP_004647
Entrez Gene 8314 Human
FunctionMutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a RING domain near the N-terminus and appears to encode a tumor suppressor. BARD1 (BRCA1-associated RING domain protein 1) and BAP1 (BRCA1-associated protein 1) have both been shown to bind to the N-terminus of BRCA1 and are potential mediators of tumor suppression. BARD1 contains an N-terminal RING domain and three tandem ankyrin repeats. The C-terminus of BARD1 contains a region with sequence homology to BRCA1, termed the BRCT domain. BAP1 is a ubiquitin hydrolase and has been shown to enhance BRCA1-mediated cell growth suppression.
Related PathwayProteaseDruggable Genome

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WB Image
Detection of BAP1 in HeLa WCE (2ug/ml)


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