Home Antibody All anti-BAK1 antibodies
Also for BAK1 (NM_001188)
|Bak antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak.|
||ELISA, WB: 1 - 2 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified (Protein A or G Sepharose)
|Homo sapiens BCL2-antagonist/killer 1 (BAK1)|
|BAK; BAK-LIKE; BCL2L7; CDN1|
|Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria (4,5). It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability (6,7).|
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Western blot analysis of Bak in L1210 cell lysates with Bak antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of Bak in L1210 cells with Bak antibody at 2 ug/mL.