Home Antibody All anti-BAIAP2 antibodies
Also for BAIAP2 (NM_017450)
|Peptide with sequence C-SGSGTLVSTV, from the C Terminus of the protein sequence according to NP_059344.1.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat
||ELISA: 1:64,000. WB 1-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens BAI1-associated protein 2 (BAIAP2), transcript variant 1|
|BAP2; FLAF3; IRSP53|
Entrez Gene 10458 Human
Entrez Gene 108100 Mouse
Entrez Gene 117542 Rat
|The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
|Druggable Genome Adherens junctionRegulation of actin cytoskeleton|
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TA302427 staining (1µg/ml) of Human Brain lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.