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Home Antibody All anti-BAG3 antibodies

Anti-BAG3 Antibody EPR3515

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307312
  • Rabbit monoclonal antibody against Bag-3(clone EPR3515)
100ul 325 3-7 Days
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WB(1)
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Also for BAG3 (NM_004281)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues between a.a. 90 and 120 in human Bag-3 was used as an immunogen.
Clone NameEPR3515 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsIP: 1:10 - 100, WB: 1:1,000 - 10,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens BCL2-associated athanogene 3 (BAG3)
Alternative NameBAG-3; BIS; CAIR-1; MFM6
Database LinkNP_004272
FunctionBcl-2-associated athanogene 3 (Bag-3) is a member of a conserved family of cyto-protective proteins that bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone acitivity in a Hip-repressible manner. It has been shown to be prominently expressed in striated muscle and colocalizes with Z-disks. Bag-3 is not required for muscle development, but appears to be critically important for maintenance of mature skeletal muscle (1-2). Bag-3 has also been shown to have anti-apoptotic activity (3). Overexpression of Bag-3 has prevented or reduced the distraction of polyubiquitinated Hsp90/Hsp70 client proteins such as Cyclin D1, Akt, glycogen synthase 3B, and p70s6 kinase, and facilitated cell survival (4).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Bag3 antibody [EPR3515]; All lanes : Anti-Bag3 antibody [EPR3515] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : MCF7 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 62 kDa.Observed band size : 80 kDa .

 

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