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Anti-B2M Antibody EP2978Y
|A synthetic peptide corresponding to residues on the C-terminus of human beta-2-microglobulin was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; IP: 1:40; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens beta-2-microglobulin (B2M)|
|beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin|
|Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (1). It is a major component forming amyloid deposits in patients with hemodialysis-associated amyloidosis (HAA), a serious complication of long-term hemodialysis (2). B2M is found to contain two antiparallel beta-sheets, each of four beta-strands with the beta-sheets being connected by a single disulfide linkage. No evidence for any regular helical structure is found (3). B2M is an example of a low molecular weight serum protein, with a prominent beta-pleated sheet structure, that may adopt the fibrillar configuration of amyloid in certain pathologic states (4). |
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Western blot - beta 2 Microglobulin antibody [EP2978Y]; All lanes : Anti-beta 2 Microglobulin antibody [EP2978Y] at 1/200000 dilution.Lane 1 : Raji cell lysate.Lane 2 : U937 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Human bone marrow lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 14 kDa.Observed band size : 14 kDa.