Home Antibody All anti-AXIN2 antibodies
Anti-AXIN2 Antibody Polyclonal
Also for AXIN2 (NM_004655)
|AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|AXIN2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|AXIN2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens axin 2 (AXIN2)|
Entrez Gene 8313 Human
Entrez Gene 12006 Mouse
Entrez Gene 29134 Rat
|AXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.|
|ES Cell Differentiation/IPSInduced pluripotent stem cellsDruggable Genome Wnt signaling pathwayPathways in cancerColorectal cancerEndometrial cancerBasal cell carcinoma|
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Western blot analysis of AXIN2 in mouse lung lysate with AXIN2 antibody at 1 ug/mL.
Immunohistochemistry of AXIN2 in rat lung tissue with AXIN2 antibody at 5 ug/mL.