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Home Antibody All anti-AURKB antibodies
UltraMAB

Anti-AURKB GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590640
  • Rabbit Polyclonal Aurora B Antibody
100ug 325 In Stock
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WB(2)
IHC(4)
ELISA(1)
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Also for AURKB (NM_004217)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman , Dog , Monkey , Mouse Concentration1.26496
Guaranteed Application *WB, ELISA, IHC Suggested Dilutions WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens aurora kinase B (AURKB), transcript variant 1
Alternative NameAIK2; AIM-1; AIM1; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK12; STK5
Database LinkNP_004208
FunctionAURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis. It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver. ARK-2 protein levels are maximal during both S and G2/M phases.
Related Pathway
Cell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY AURKB (RC210288, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AURKB.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-AURKB polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
ELISA Image
ELISA: Aurora B Antibody
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-AURKB rabbit polyclonal antibody. (TA590640)
IHC Image
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-AURKB rabbit polyclonal antibody. (TA590640)
IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-AURKB rabbit polyclonal antibody. (TA590640)
IHC Image
Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-AURKB rabbit polyclonal antibody. (TA590640)

 

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