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Home Antibody All anti-AURKB antibodies

Anti-AURKB Antibody EPR1010

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307319
  • Rabbit monoclonal antibody against Aurora-B(clone EPR1010)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418144) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for AURKB (NM_004217)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Aurora-B was used as an immunogen.
Clone NameEPR1010 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens aurora kinase B (AURKB), transcript variant 1
Alternative NameAIK2; AIM-1; AIM1; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK12; STK5
Database LinkNP_004208
FunctionAurora-B is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process. Aurora-B is known to be involved in the regulation of centrosome function, bipolar spindle assembly and chromosome segregation. Aurora kinases are localized at the centrosomes of interphase cells, at the poles of the bipolar spindle and in the midbody of the mitotic apparatus. Substrates identified for the Aurora-B kinases include a kinesin-like motor protein, spindle apparatus proteins, histone H3 protein, kinetochore protein and the tumor suppressor protein p53 (1). Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. Identification of Aurora kinases as RasGAP Src homology 3 domain binding protein, also implicates these kinases as potential effectors in the Ras pathway relevant to oncogenesis (2).
Related Pathway
Cell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Aurora B antibody [EPR1010]; All lanes : Anti-Aurora B antibody [EPR1010] at 1/1000 dilution.Lane 1 : HeLa treated with nocodazole cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Fetal thymus cell lysate.Lane 4 : A549 cell lysates.Lysates/proteins at 10 ug per lane.Predicted band size : 39 kDa.Observed band size : 39 kDa.

 

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