Homo sapiens activating transcription factor 2 (ATF2), transcript variant 1
Synonyms:
CRE-BP1; CREB2; HB16; TREB7
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr71 of human ATF-2 was used as immunogen. The antibody only detects ATF-2 phosphorylated on Threonine 71.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. [provided by RefSeq].
Related Pathway
MAPK signaling pathway
TGF Beta Signaling Pathway
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Western blot analysis on HeLa cell lysate using anti-Phospho-ATF-2 (pT71) RabMAb (TA303460); dilution 1:10,000. Cells were (1) untreated, and (2) treated with Anisomycin.
