Home Antibody All anti-ARFGEF2 antibodies
Anti-ARFGEF2 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for ARFGEF2 (NM_006420)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
|ELISA, IHC, IF
||ELISA: 1:100-1:2000; IHC: 1:350; IF: 1:87
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ARFGEF2)|
|BIG2; dJ1164I10.1; PVNH2|
Entrez Gene 10564 Human
|BIG2 promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. ARFGEF2 plays an important role in vesicular and membrane trafficking from the trans-golgi network. It is also involved in the activation of ARFs (1,5, and 6) by accelerating replacement of bound GDP with GTP. It also acts as the activator of ADP-ribosylation factor GTPases that are essential for regulating vesicular traffic among intracellular organelles.|
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Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunofluorescent staining of human cell line U-251 MG shows no positivity.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.