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Home Antibody All anti-APP antibodies

Anti-APP TRUEMAB Antibody Clone OTI3D11

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500970 anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI3D11 (formerly 3D11) 100ul $325 In Stock
LC424694 APP HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500970 Carrier-free (BSA/glycerol-free) APP mouse monoclonal antibody, clone OTI3D11 (formerly 3D11) 100ug $450 3-4 weeks
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WB(1)
IHC(1)
IF(2)
FC(1)

OriGene Data

ImmunogenFull length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.
Clone NameClone OTI3D11 IsotypeIgG1
Species ReactivityHuman Concentration0.54 mg/ml
Guaranteed Application *WB, IHC, IF, FC Suggested DilutionsWB 1:2000, IHC 1:50, IF 1:100, Flow 1:100
Predicted MW Explanation 87.0 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1
Alternative NameAAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Database LinkNP_000475
Entrez Gene 351 Human
FunctionThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Related PathwayTransmembraneDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (RC221339, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP.
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Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500970, Dilution 1:50)
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Anti-APP mouse monoclonal antibody (TA500970) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY APP(RC221339).
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Immunofluorescent staining of HepG2 cells using anti-APP mouse monoclonal antibody (TA500970).
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HEK293T cells transfected with either pCMV6-ENTRY APP(RC221339)(Red) or empty vector control plasmid(Blue) were immunostained with anti-APP mouse monoclonal(TA500970), and then analyzed by flow cytometry.
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