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Anti-APEX1 Antibody EPR4022
Also for APEX1 (NM_001641)
|A synthetic peptide corresponding to residues near the N-terminus in human Ape 1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||IHC: 1 : 100 - 250, WB: 1:10,000-50,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1|
|APE; APE1; APEN; APEX; APX; HAP1; REF1|
|Apurinic endonuclease (Ape 1) functions as a major DNA repair enzyme that is essential for embryogenesis and cell viability (1). It is involved in the base excision repair (BER) pathway and acts as a reduction-oxidation signaling factor to maintain transcription factors in an active reduced state (2). Ape 1 plays a critical role as a transcriptional coactivator for different transcription factors (i.e. AP-1, NF-kappaB, p53) in controlling different cellular processes such as apoptosis, proliferation, and differentiation (3). Elevated levels of Ape 1 have been found in cancers such as ovarian, cervical, and prostate (4).|
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Western blot - APE1 antibody [EPR4022]; All lanes : Anti-APE1 antibody [EPR4022] at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Raji cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution.Predicted band size : 36 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - APE1 antibody [EPR4022]; TA307529, at a 1/100 dilution, staining APE1 in formalin fixed, paraffin embedded (1) Human tonsil tissue and (2)Human kidney tissue by Immunohistochemistry. Detection: DAB staining.