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Home Antibody All anti-APEX1 antibodies

Anti-APEX1 Antibody EPR4022

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307529
  • Rabbit monoclonal antibody against Ape 1(clone EPR4022)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400618) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for APEX1 (NM_001641)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus in human Ape 1 was used as an immunogen.
Clone NameEPR4022 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC: 1 : 100 - 250, WB: 1:10,000-50,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1
Alternative NameAPE; APE1; APEN; APEX; APX; HAP1; REF1
Database LinkNP_001632
FunctionApurinic endonuclease (Ape 1) functions as a major DNA repair enzyme that is essential for embryogenesis and cell viability (1). It is involved in the base excision repair (BER) pathway and acts as a reduction-oxidation signaling factor to maintain transcription factors in an active reduced state (2). Ape 1 plays a critical role as a transcriptional coactivator for different transcription factors (i.e. AP-1, NF-kappaB, p53) in controlling different cellular processes such as apoptosis, proliferation, and differentiation (3). Elevated levels of Ape 1 have been found in cancers such as ovarian, cervical, and prostate (4).
Related Pathway

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WB Image
Western blot - APE1 antibody [EPR4022]; All lanes : Anti-APE1 antibody [EPR4022] at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Raji cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution.Predicted band size : 36 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - APE1 antibody [EPR4022]; TA307529, at a 1/100 dilution, staining APE1 in formalin fixed, paraffin embedded (1) Human tonsil tissue and (2)Human kidney tissue by Immunohistochemistry. Detection: DAB staining.

 

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