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Home Antibody All anti-APAF1 antibodies

Anti-APAF1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305972 Rabbit Polyclonal Apaf1 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenApaf1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Apaf1. The sequences of the immunogenic peptide are identical between human and mouse.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1-2ug/ml; IHC: 1ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 2
Alternative NameAPAF-1; CED4
Database LinkNP_001151
Entrez Gene 317 Human
Entrez Gene 11783 Mouse
Entrez Gene 78963 Rat
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Apaf1 can also associate with caspase-4 and caspase-8 (4). Apaf1 is ubiquitously expressed in human tissues .
Related PathwayDruggable Genome p53 signaling pathwayApoptosisAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)Huntington's diseaseMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Apaf1 in K562 cell lysate with Apaf1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
Immunohistochemistry of Apaf1 in human heart tissue with Apaf1 antibody at 1 ug/ml.


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