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Home Antibody All anti-ANTXR1 antibodies

Anti-ANTXR1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306122 Rabbit Polyclonal ATR Antibody 100ug $325 3-7 Days
LC413252 ANTXR1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for ANTXR1 (NM_018153)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenATR antibody was raised against a peptide corresponding to 13 amino acids near the C-terminus of human ATR.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens anthrax toxin receptor 1 (ANTXR1), transcript variant 3
Alternative NameATR; GAPO; TEM8
Database LinkNP_060623
Entrez Gene 84168 Human
Entrez Gene 69538 Mouse
Entrez Gene 362393 Rat
FunctionThe Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of ATR in K562 cell lysates with ATR antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry of ATR in K562 cells with ATR antibody at 2 ug/mL.


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