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Anti-AMPH Antibody EP2061Y
Also for AMPH (NM_001635)
|A synthetic peptide corresponding to residues near C-terminus of human Amphipysin was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:20000 - 1:100000; IP: 1:20; IHC-P: 1:100 - 1:250; ICC: 1:250 - 1:500; FC: 1:160
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens amphiphysin (AMPH), transcript variant 1|
|Amphiphysin, a neuronal protein first identified in chicken synaptic membranes, is the autoantigen of Stiff-Man Syndrome (SMS) associated with breast cancer. Patient autoantibodies have a distinct pattern of reactivity with amphiphysin, and the dominant autoepitope is located in its C-terminal region, which contains an SH3 domain (1). Amphiphysin is expressed in many neurons, certain endocrine cell types, and spermatocytes (2). study suggests a link between amphiphysin I expression in cancer and amphiphysin I autoimmunity. The enhanced expression of amphiphysin I in some forms of cancer supports the hypothesis that amphiphysin family members may play a role in the biology of cancer cells (3). |
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Western blot - Amphiphysin antibody [EP2061Y]; All lanes : Anti-Amphiphysin antibody [EP2061Y] at 1/100000 dilution.Lane 1 : Human brain tissue lysate.Lane 2 : Mouse brain tissue lysate.Lane 3 : Rat brain tissue lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 76 kDa.Observed band size : 128 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Amphiphysin antibody [EP2061Y]; ab76124 at 1/100 dilution, staining Amphiphysin in human brain by Immunohistochemistry using paraffin-embedded tissue.