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Home Antibody All anti-AMBRA1 antibodies

Anti-AMBRA1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306558
  • Rabbit Polyclonal Ambra1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413575) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for AMBRA1 (NM_017749)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenAmbra1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Ambra1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens autophagy/beclin-1 regulator 1 (AMBRA1), transcript variant 2
Alternative NameDCAF3; WDR94
Database LinkNP_060219
Entrez Gene 55626 Human
Entrez Gene 228361 Mouse
Entrez Gene 59319 Rat
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death . Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Ambra1 in 3T3 cell lysate with Ambra1 antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of Ambra1 in human brain with Ambra1 antibody at 5 ug/ml.

 

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