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Home Antibody All anti-ALDH2 antibodies

Anti-ALDH2 Antibody EPR4494

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307675
  • Rabbit monoclonal antibody against Aldh2(clone EPR4494)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400231) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for ALDH2 (NM_000690)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Aldh2 was used as an immunogen.
Clone NameEPR4494 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1
Alternative NameALDH-E2; ALDHI; ALDM
Database LinkNP_000681
FunctionAldh2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. Aldh2 encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-ALDH2 antibody [EPR4494]; All lanes : Anti-ALDH2 antibody [EPR4494] at 1/1000 dilution.Lane 1 : HepG2 lysates .Lane 2 : Human heart lysates .Lane 3 : Fetal liver lysates .Lane 4 : Mouse liver lysates .Lane 5 : Rat liver lysates .Lane 6 : Mouse lung lysates .Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 56 kDa.

 

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