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Anti-ALDH2 Antibody EPR4494
Also for ALDH2 (NM_000690)
|A synthetic peptide corresponding to residues in human Aldh2 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
|Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1|
|ALDH-E2; ALDHI; ALDM|
|Aldh2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. Aldh2 encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix (1).|
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Western blot - Anti-ALDH2 antibody [EPR4494]; All lanes : Anti-ALDH2 antibody [EPR4494] at 1/1000 dilution.Lane 1 : HepG2 lysates .Lane 2 : Human heart lysates .Lane 3 : Fetal liver lysates .Lane 4 : Mouse liver lysates .Lane 5 : Rat liver lysates .Lane 6 : Mouse lung lysates .Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 56 kDa.