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Home Antibody All anti-AKIRIN2 antibodies

Anti-AKIRIN2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306646
  • Rabbit Polyclonal Akirin2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413339) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for AKIRIN2 (NM_018064)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenAkirin2 antibody was raised against a 15 amino acid peptide near the center of the human Akirin2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens akirin 2 (AKIRIN2)
Alternative NameC6orf166; dJ486L4.2; FBI1
Database LinkNP_060534
Entrez Gene 55122 Human
Entrez Gene 433693 Mouse
FunctionThe highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Akirin2 in mouse brain tissue lysate with Akirin2 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.

 

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