Home Antibody All anti-AKIRIN2 antibodies
Also for AKIRIN2 (NM_018064)
|Akirin2 antibody was raised against a 15 amino acid peptide near the center of the human Akirin2.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens akirin 2 (AKIRIN2)|
|C6orf166; dJ486L4.2; FBI1|
Entrez Gene 55122 Human
Entrez Gene 433693 Mouse
|The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.|
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Western blot analysis of Akirin2 in mouse brain tissue lysate with Akirin2 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.