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Home Antibody All anti-AKIRIN1 antibodies

Anti-AKIRIN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306644
  • Rabbit Polyclonal Akirin1 Antibody
100ug 325 3-7 Days
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WB(1)
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Also for AKIRIN1 (NM_001136275)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenAkirin1 antibody was raised against a 16 amino acid peptide near the amino terminus of the human Akirin1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens akirin 1 (AKIRIN1), transcript variant 2
Alternative NameC1orf108; STRF2
Database LinkNP_001129747
FunctionThe highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Related Pathway

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WB Image
Western blot analysis of Akirin1 in A549 cell lysate with Akirin1 antibody at (A) 1 and (B) 2 µg/ml.

 

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