Home Antibody All anti-AKAP1 antibodies
Anti-AKAP1 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for AKAP1 (NM_003488)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
|ELISA, IHC, IF
||ELISA: 1:100-1:2000; IHC: 1:500; IF: 1:125
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens A kinase (PRKA) anchor protein 1 (AKAP1), transcript variant 1|
|AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1; PPP1R43; PRKA1; SAKAP84; TDRD17|
|The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.|
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Immunohistochemistry: AKAP1 Antibody - Most normal tissues and malignant tissues showed strong cytoplasmic immunoreactivity. Decidual cells in placenta were moderately stained. Bile ducts, renal glomeruli and stromal cells along with some of the malignant lymphomas and renal cancers were weakly stained or negative. Image and statement courtesy of the Human Protein Atlas (HPA).
Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunofluorescent staining of human cell line A-431 shows positivity in mitochondria.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.