Home Antibody All anti-ADRA2A antibodies
Also for ADRA2A (NM_000681)
|Peptide with sequence C-TERRPNGLGPERS, from the internal region of the protein sequence according to NP_000672.2.|
|Test: Mouse. Expected from seq similarity: Human, Mouse, Rat, Dog
||Lot dependent; please refer to CoA along with shipment
||WB: 1ug/ml. IF: 3-5ug/ml.
|0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
|Homo sapiens adrenoceptor alpha 2A (ADRA2A)|
|ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32|
Entrez Gene 150 Human
Entrez Gene 11551 Mouse
Entrez Gene 25083 Rat
Entrez Gene 486888 Dog
|Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq]. |
|GPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interaction|
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