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Anti-ADA Antibody EPR4438
|A synthetic peptide corresponding to residues in human ADA was used as an immunogen.|
||Tissue culture supernatant
|Rat, Human (Does not react with: Mouse)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC: 1:250 - 1:500
|Does not react with Mouse. Is unsuitable for Flow Cyt or IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens adenosine deaminase (ADA)|
|adenosine aminohydrolase; adenosine deaminase|
Entrez Gene 100 Human
Entrez Gene 24165 Rat
|ADA is an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this protein and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia (1).|
|Druggable Genome Purine metabolismMetabolic pathwaysPrimary immunodeficiency|
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Western blot - ADA antibody [EPR4438]; All lanes : Anti-ADA antibody [EPR4438] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Human fetal thymus lysate.Lane 3 : Rat kidney tissue lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 41 kDa.Observed band size : 41 kDa.