Home Antibody All anti-ACVR2A antibodies
Also for ACVR2A (NM_001616)
|Recombinant fragment corresponding to a region within amino acids 267 and 513 of Activin A Receptor type IIA (Uniprot ID#P27037)|
|Human (Predicted: Mouse, Rat, Bovine)
||Lot dependent; please refer to CoA along with shipment
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Rat (100%), Bovine (100%)
|Homo sapiens activin A receptor, type IIA (ACVR2A), transcript variant 2|
Entrez Gene 92 Human
Entrez Gene 11480 Mouse
Entrez Gene 29263 Rat
|This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq]|
|Protein KinaseTransmembraneDruggable Genome Cytokine-cytokine receptor interactionTGF-beta signaling pathway|
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Sample (30 ug of whole cell lysate). A: Hela. B: Hep G2 . 7.5% SDS PAGE. TA308578 diluted at 1:10000.