Home Antibody All anti-ACTN4 antibodies
Also for ACTN4 (NM_004924)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 206 and 512 of alpha Actinin 4|
|WB, IHC, IF
||WB:1:500-1:3000; IHC:1:500; IF:1:100-1:500;
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens actinin, alpha 4 (ACTN4)|
|ACTININ-4; FSGS; FSGS1|
| Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq]|
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A: A431 B: HepG2 (anti-ACTN4 antibody diluted at 1:1000)
A: NIH-3T3 (anti-ACTN4 antibody diluted at 1:1000)
A: Mouse brain (anti-ACTN4 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded A549 xenograft, using alpha Actinin 4(anti-ACTN4 antibody) antibody at 1:500 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using alpha Actinin 4(anti-ACTN4 antibody) antibody at 1:200 dilution.