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Home Antibody All anti-ACTN4 antibodies

Anti-ACTN4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308476
  • Rabbit Polyclonal antibody to alpha Actinin 4 (actinin, alpha 4)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417652) , 20ug
100ul 325 3-7 Days
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WB(3)
IHC(1)
IF(1)
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Also for ACTN4 (NM_004924)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 206 and 512 of alpha Actinin 4
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1.03mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB:1:500-1:3000; IHC:1:500; IF:1:100-1:500;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens actinin, alpha 4 (ACTN4)
Alternative NameACTININ-4; FSGS; FSGS1
Database LinkNP_004915
Function Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq]
Related Pathway
Adherens junction
Focal Adhesion
Hemostasis

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WB Image
A: A431 B: HepG2 (anti-ACTN4 antibody diluted at 1:1000)
WB Image
A: NIH-3T3 (anti-ACTN4 antibody diluted at 1:1000)
WB Image
A: Mouse brain (anti-ACTN4 antibody diluted at 1:1000)
IHC Image
Immunohistochemical analysis of paraffin-embedded A549 xenograft, using alpha Actinin 4(anti-ACTN4 antibody) antibody at 1:500 dilution.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using alpha Actinin 4(anti-ACTN4 antibody) antibody at 1:200 dilution.

 

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