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Home Antibody All anti-ACTN4 antibodies

Anti-ACTN4 Antibody EPR4410

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307265
  • Rabbit monoclonal antibody against Alpha-Actinin 4(clone EPR4410)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417652) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for ACTN4 (NM_004924)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Alpha-Actinin 4 was used as an immunogen.
Clone NameEPR4410 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens actinin, alpha 4 (ACTN4)
Alternative NameACTININ-4; FSGS; FSGS1
Database LinkNP_004915
FunctionAlpha-actinin is a ubiquitously expressed cytoskeletal protein found in numerous actin structures. It consists of an N-terminal actin-binding domain, a central rod domain, and a C-terminal domain; the protein functions as a homodimer to cross-link actin filaments. The rod domain determines the distance between cross-linked actin filaments and also serves as an interaction site for several cytoskeletal and signaling proteins (1). Alpha-actinin 4 is a non-muscle isoform version of alpha-actinin that is concentrated in the cytoplasm (2). It plays a role in cell motility, invasion, and metastasis of cancer cells (3). Alpha-actinin 4 is commonly expressed in filopodia, lamellipodia, stress fibers, and sites of adhesion (4).
Related Pathway
Adherens junction
Focal Adhesion
Hemostasis

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - alpha Actinin 4 antibody [EPR4410]; All lanes : Anti-alpha Actinin 4 antibody [EPR4410] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF-7 cell lysate.Lane 3 : C2C12 cell lysate.Lane 4 : A673 cell lysate.Lane 5 : L6 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 105 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - alpha Actinin 4 antibody [EPR4410]; TA307265, at 1/100 dilution, staining alpha Actinin 4 in paraffin-embedded Human kidney tissue by Immunohistochemistry.

 

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