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Also for ACTA2 (NM_001613)
|Peptide with sequence EEEDSTALVC, from the N Terminus of the protein sequence according to NP_001604.1.|
|Tested: Human, Mouse, Rat, Pig. Expected from sequence similarity: Human, Mouse, Rat, Dog
||Lot dependent; please refer to CoA along with shipment
||WB: 0.3-1.0 µg/ml. IHC: 2-4 µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|IHC: In paraffin embedded Human and Murine Lung shows staining of the alveolar walls.
|Homo sapiens actin, alpha 2, smooth muscle, aorta (ACTA2), transcript variant 2|
|AAT6; ACTSA; MYMY5|
Entrez Gene 59 Human
Entrez Gene 11475 Mouse
Entrez Gene 81633 Rat
Entrez Gene 477587 Dog
|The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].|
| Vascular smooth muscle contraction|
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TA302403 staining (0.3 ug/ml) of Human Duodenum lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence
TA302403 (2.5 ug/ml) staining of paraffin embedded Human Lung (top) and Mouse Lung (bottom). Trypsin-mediated antigen retrieval, HRP-staining. Bar in right lower corner represents 50um.