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Anti-ACHE Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA308775 Rabbit polyclonal antibody to AChE (acetylcholinesterase (Yt blood group)) 100ul $325 3-7 Days
LC425009 ACHE HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 551 and 614 of AChE (Uniprot ID#P22303)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Rat, Cat, Guinea pig, Xenopus laevis, Zebrafish, Bovine, Rhesus Monkey) Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 68kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rat (93%), Zebrafish (86%), Xenopus laevis (85%), Cat (100%), Rhesus Monkey (100%), Bovine (100%), Guinea pig (100%)

Reference Data

Target NameHomo sapiens acetylcholinesterase (Yt blood group) (ACHE), transcript variant E4-E6
Alternative NameACEE; ARACHE; N-ACHE; YT
Database LinkNP_000656
Entrez Gene 43 Human
Entrez Gene 83817 Rat
Entrez Gene 713370 Monkey
FunctionAcetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq]
Related PathwayDruggable Genome Glycerophospholipid metabolism

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: Hep G2 . B: Molt-4 . 7.5% SDS PAGE. TA308775 diluted at 1:500

IHC Image
AChE antibody [C3], C-term detects AChE protein at cytoplasm dot-like staining on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. AChE antibody [C3], C-term (TA308775) dilution: 1:250.

IF Image
Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using AChE(TA308775) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:2000.


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