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Home Antibody All anti-ABI1 antibodies

Anti-ABI1 PHOSPHO Antibody EP3954

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307217
  • Rabbit monoclonal antibody against ABI1 Phospho (pY435)(clone EP3954) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for ABI1 (NM_005470)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 435 of human ABI1 was used as an immunogen. This antibody only detects ABI1 phosphorylated at tyrosine 435.
Clone NameEP3954 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; ICC: 1:250 - 1:500; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens abl-interactor 1 (ABI1), transcript variant 1
Alternative NameABI-1; ABLBP4; E3B1; NAP1BP; SSH3BP; SSH3BP1
Database LinkNP_005461
FunctionABI1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, this protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling (1). In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. It regulates ABL1/c-Abl-mediated phosphorylation of MENA, and widely expressed, with highest expression in brain (2).
Related Pathway
EGFR1 Signaling Pathway

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WB Image
Western blot - SSH3BP1 (phospho Y435) antibody [EP3954]; All lanes : Anti-SSH3BP1 (phospho Y435) antibody [EP3954] at 1/10000 dilution.Lane 1 : Jurkat cell lysate, untreated.Lane 2 : Jurkat cell lysate, treated with pervanadate.Lysates/proteins at 10 µg per lane.Predicted band size : 55 kDa.

 

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