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Over 1000 citations of OriGene cDNA clones
Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation by inhibiting angiotensin-(1-7)/Mas signaling Oncol. Rep. May 2015 [MAS1]

Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype Med. Oncol. May 2015 [LDHB]

Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects J. Immunol. Apr 2015 [MC3R]

C5aR is frequently expressed in metastatic renal cell carcinoma and plays a crucial role in cell invasion via the ERK and PI3 kinase pathways Oncol. Rep. Apr 2015 [C5ar1]

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GHSR (NM_198407) Stable Cell Line

Catalog #:SL500060Price:$12888    technical questions?
Description:Human Ghrelin Receptor GHSR Stable cell Line - CHO-K1
Gene:GHSR
Other names: GHDP
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay
Background:The growth hormone secretagagogue receptor (GHSR), also known as GHSR subtype 1a (GHSR1a), is a Gq/11 protein-coupled receptor that is widely expressed in peripheral tissues and various regions of the brain such as the pituitary gland, hypothalamus, thalamus, cortex, and hippocampus. GHSR plays a critical role in maintaining energy balance and neuronal health and is a characterized therapeutic target for obesity and metabolic syndrome.
Figure 1. Calcium dose-response for ghrelin stimulation of CHO/GHSR cells compared to untransfected CHO-K1 cells. The passage 1and passage 3 of CHO/GHSR cells that stably express the GHSR (Green and blue circles) or untransfected CHO-K1 cells which is the same passage as CHO/GHSR MCB (black triangle) were loaded with Fluo-4 NW (Invitrogen), then stimulated with the indicated concentration of ghrelin. The change in intracellular calcium was measured by a FlexStation III fluorescent plate reader. Data poins represent the average+/- standard deviation of triplicate determinations.

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