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Over 1000 citations of OriGene cDNA clones
Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol Drug Metab. Dispos. Aug 2015 [CYP2J2]

Theaflavin-3,3'-digallate, a black tea polyphenol, stimulates lipolysis associated with the induction of mitochondrial uncoupling proteins and AMPK–FoxO3A–MnSOD pathway in 3T3-L1 adipocytes Journal of Functional Foods Aug 2015 [SOD2]

NFkB is activated by multiple mechanisms in hairy cell leukemia Genes Chromosomes Cancer Jul 2015 [PITX1]

Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets Genes Chromosomes Cancer Jul 2015 [CMTM2]

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GHSR (NM_198407) Stable Cell Line

Catalog #:SL500060Price:$12888    technical questions?
Description:Human Ghrelin Receptor GHSR Stable cell Line - CHO-K1
Gene:GHSR
Other names: GHDP
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay
Background:The growth hormone secretagagogue receptor (GHSR), also known as GHSR subtype 1a (GHSR1a), is a Gq/11 protein-coupled receptor that is widely expressed in peripheral tissues and various regions of the brain such as the pituitary gland, hypothalamus, thalamus, cortex, and hippocampus. GHSR plays a critical role in maintaining energy balance and neuronal health and is a characterized therapeutic target for obesity and metabolic syndrome.
Figure 1. Calcium dose-response for ghrelin stimulation of CHO/GHSR cells compared to untransfected CHO-K1 cells. The passage 1and passage 3 of CHO/GHSR cells that stably express the GHSR (Green and blue circles) or untransfected CHO-K1 cells which is the same passage as CHO/GHSR MCB (black triangle) were loaded with Fluo-4 NW (Invitrogen), then stimulated with the indicated concentration of ghrelin. The change in intracellular calcium was measured by a FlexStation III fluorescent plate reader. Data poins represent the average+/- standard deviation of triplicate determinations.

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