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Over 1000 citations of OriGene cDNA clones
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue Sci Rep 2017 [GRIN2A]

A functional DC cross talk promotes human ILC homeostasis in humanized mice Blood Advances 2017 [IL7]

Cloning, expression, purification of active recombinant human 12R-LOX enzyme and its inhibition by Acalypha indica extracts PeerJ Preprints 2017 [ALOX12B]

Collagen beta (1- O ) galactosyltransferase 1(GLT25D1)is required for the secretion of high molecular weight adiponectin and affects lipid accumulation Biosci. Rep. 2017 [PLOD3]

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GHSR (NM_198407) Stable Cell Line

Catalog #:SL500060Price:$12888    technical questions?
Description:Human Ghrelin Receptor GHSR Stable cell Line - CHO-K1
Gene:GHSR
Other names: GHDP; GHDP
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay
Background:The growth hormone secretagagogue receptor (GHSR), also known as GHSR subtype 1a (GHSR1a), is a Gq/11 protein-coupled receptor that is widely expressed in peripheral tissues and various regions of the brain such as the pituitary gland, hypothalamus, thalamus, cortex, and hippocampus. GHSR plays a critical role in maintaining energy balance and neuronal health and is a characterized therapeutic target for obesity and metabolic syndrome.
Figure 1. Calcium dose-response for ghrelin stimulation of CHO/GHSR cells compared to untransfected CHO-K1 cells. The passage 1and passage 3 of CHO/GHSR cells that stably express the GHSR (Green and blue circles) or untransfected CHO-K1 cells which is the same passage as CHO/GHSR MCB (black triangle) were loaded with Fluo-4 NW (Invitrogen), then stimulated with the indicated concentration of ghrelin. The change in intracellular calcium was measured by a FlexStation III fluorescent plate reader. Data poins represent the average+/- standard deviation of triplicate determinations.

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