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Over 1000 citations of OriGene cDNA clones
1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists Bioorg. Med. Chem. Apr 2016 [DRD3]

A role for ABCG2 beyond drug transport: regulation of autophagy Autophagy Mar 2016 [ABCG2]

An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal NATURE COMMUNICATIONS Mar 2016 [U2AF2]

Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL Molecular Therapy nucleic acid Mar 2016 [AXL]

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MLNR (NM_001507) Stable Cell Line

Catalog #:SL500046Price:$12888    technical questions?
Description:Human Motilin Receptor MLNR Stable cell Line - CHO-K1
Gene:MLNR
Other names: GPR38; MTLR1
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay: Calcium dose-response for moltilin stimulation
Background:Motilin Receptors (MLNRs) are Gq/11-protein-coupled receptors that mediate progastrokinetic effects. MLNRs are found at their highest concentrations in the nerves of the antral wall of the stomach and are also found at significant levels throughout the smooth muscle of the upper gastrointestinal (GI) tract and in the enteric nervous system. Motilin receptor promotes gastric emptying after food intake and increases smooth muscle contraction in the GI tract, and thus, is clinically a potential drug target for the treatment of hypomotility disorders.
Figure 1. Calcium dose-response for moltilin stimulation of CHO/MLNR cells (MCB) compared to untransfected CHO-K1 cells. The passage 1, passage 7 and passage 13 of CHO/MLNR MCB cells that stably express the MLNR (blue, red and green circle) or untransfected CHO-K1 cells which is the same passage as CHO/MLNR MCB (black circle) were loaded with Fluo-4 NW (Invitrogen), then stimulated with the indicated concentration of moltilin. The change in intracellular calcium was measured by a FlexStation III fluorescent plate reader. Data poins represent the average+/- standard deviation of triplicate determinations.

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