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Over 1000 citations of OriGene cDNA clones
A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors J Biomol Screen, Feb 2014. [GLP1R]

A Long Noncoding RNA, CHRF Regulates Cardiac Hypertrophy by Targeting miR-489 Circ. Res., Feb 2014. [Myd88]

A novel mutation of hyaluronan synthase 2 gene in chinese children with ventricular septal defect PLoS ONE, Feb 2014. [HAS2]

Activation and Inhibition of Thermosensitive TRP Channels by Voacangine, an Alkaloid Present in Voacanga africana, an African Tree J. Nat. Prod., Feb 2014. [TRPV3]

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MLNR (NM_001507) Stable Cell Line

Catalog #:SL500046Price:$12888    technical questions?
Description:Human Motilin Receptor MLNR Stable cell Line - CHO-K1
Gene:MLNR
Other names: GPR38; MTLR1
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay: Calcium dose-response for moltilin stimulation
Background:Motilin Receptors (MLNRs) are Gq/11-protein-coupled receptors that mediate progastrokinetic effects. MLNRs are found at their highest concentrations in the nerves of the antral wall of the stomach and are also found at significant levels throughout the smooth muscle of the upper gastrointestinal (GI) tract and in the enteric nervous system. Motilin receptor promotes gastric emptying after food intake and increases smooth muscle contraction in the GI tract, and thus, is clinically a potential drug target for the treatment of hypomotility disorders.
Figure 1. Calcium dose-response for moltilin stimulation of CHO/MLNR cells (MCB) compared to untransfected CHO-K1 cells. The passage 1, passage 7 and passage 13 of CHO/MLNR MCB cells that stably express the MLNR (blue, red and green circle) or untransfected CHO-K1 cells which is the same passage as CHO/MLNR MCB (black circle) were loaded with Fluo-4 NW (Invitrogen), then stimulated with the indicated concentration of moltilin. The change in intracellular calcium was measured by a FlexStation III fluorescent plate reader. Data poins represent the average+/- standard deviation of triplicate determinations.

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