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OriGene shRNA in recent publications
Identification of CTCF as a master regulator of the clustered protocadherin genes Nucleic Acids Res., Apr 2012; 40: 3378 - 3391. [CTCF ]

Transducin-like Enhancer of Split-1 (TLE1) Combines with Forkhead Box Protein G1 (FoxG1) to Promote Neuronal Survival J. Biol. Chem., Apr 2012; 287: 14749 - 14759. [Tle1 ]

Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia J. Neurosci., Apr 2012; 32: 5024 - 5038. [GFP-tagged siRNA]

CCR7/CCL19 Controls Expression of EDG-1 in T Cells J. Biol. Chem., Apr 2012; 287: 11656 - 11664. [CCL19 ]

RNA Interference

RNA interference (RNAi) is a gene-silencing process that targets mRNA hence lowering protein expression. The key RNAi substrates regulating this process are shRNA, miRNA and siRNA. While miRNAs are naturally occurring non-coding small RNAs playing important role in gene-expression regulation, gene-specific shRNAs and siRNAs are powerful tools to effectively knockdown target gene expression. OriGene provides comprehensive and innovative RNAi tools for guaranteed gene silencing.

Pre-designed against human, mouse and rat genes.
Pre-designed against human, mouse & rat genes
Pre-designed against human & mouse.
Transfection reagent for siRNA
and plasmid delivery.
Custom shRNA service.
qPCR assays for miRNA detection.
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Benefits of choosing different RNAi substrates offered by OriGene based on research application

  siRNA shRNA miRNA Expression
Gene-Specific Knockdown Yes Yes No, regulates multiple genes
Transient Transfection Yes Yes Yes
Stable Transfection No Yes Yes
Infection No Yes No
Performance Guarantee Yes Yes Fully Sequenced
Renewable RNAi Resource No Yes Yes
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