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Home Recombinant Human Proteins All CTNNB1 Proteins

CTNNB1 (NM_001904) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP710027 Recombinant protein of human human catenin (cadherin-associated protein), beta 1(CTNNB1), full length, with C-terminal DDK tag, expressed in sf9 cells, 20 ug (Larger pack size?) 399 In Stock
UM500014 CTNNB1 mouse monoclonal antibody, clone UMAB14 $468 In Stock
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Also for CTNNB1 (NM_001904)
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OriGene Data
Species:Human Expression Host:Sf9 cells
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC208947, encoding human full-length CTNNB1
Tag:C-terminal DDK Predicted MW:85 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Protein Families: ES Cell Differentiation/IPSTranscription FactorsDruggable Genome
Protein Pathways: Wnt signaling pathwayFocal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationMelanogenesisMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_001895 RefSeq Size: 3697 RefSeq ORF: 2346
LocusID: 1499 Cytogenetic: 3p21  
Synonyms : armadillo; CTNNB; MRD19
Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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