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Home Recombinant Human Proteins All STAT5B Proteins

STAT5B (NM_012448) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP309429 Recombinant protein of human signal transducer and activator of transcription 5B (STAT5B), 20 ug (Larger pack size?) 680 In Stock
TA314575 Rabbit polyclonal STAT5B (Ab-731) antibody $325 In Stock
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Also for STAT5B (NM_012448)
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC209429. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:89.7 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Mass Spec Validation: This protein has been positively validated by MS/MS by Dr. Robert Moritz at The Institute of Systems Biology.
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Stem cell relevant signaling - JAK/STAT signaling pathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome
Protein Pathways: ErbB signaling pathwayChemokine signaling pathwayJak-STAT signaling pathwayPathways in cancerChronic myeloid leukemiaAcute myeloid leukemiaMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_036580 RefSeq Size: 5171 RefSeq ORF: 2364
LocusID: 6777 Cytogenetic: 17q11.2  
Synonyms : STAT5
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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