Promotion ends on May 1st.
||RefSeq Size: 2214
||RefSeq ORF: 588|
|Synonyms : FP497|
|Summary: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]. |
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**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich